Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells
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منابع مشابه
Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.
BACKGROUND A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in mid...
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Insulin-like growth factors (IGFs) are known to have potent antiapoptotic activity. The antiestrogen ICI 182,780 (ICI) is a potent inhibitor of MCF7 human breast cancer cell growth and has recently been reported to act as an antiproliferative agent in part via upregulation of expression of insulin-like growth factor binding proteins (IGFBPs) -3 and -5, which attenuate the bioactivity of IGFs in...
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the genetic polymorphism of insulin-like growth factor binding protein ( igfbp-3 ) and its association with the growth traits namely condition factor, body weight, and total length were investigated in common carp cyprinus carpio using pcr- single strand conformation polymorphism (sscp) technique. caudal fin clips from 120 c. carpio , aging 5 months, were used in this study and a 330 bp dna fra...
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Objectives The loss of muscle mass in older adults is attributed to the impaired ability of the skeletal muscle in response to anabolic stimuli and the increased activation of the proteolytic signaling pathway. With increasing age, plasma concentrations of circulating anabolic hormones and growth factors, e.g. testosterone, Insulin-like Growth Factor-1 (IGF-1) and Insulin-like Growth Factor Bin...
متن کاملTransferrin is an insulin-like growth factor-binding protein-3 binding protein.
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) possesses both growth-inhibitory and -potentiating effects on cells that are independent of IGF action and are mediated through specific IGFBP-3 binding proteins/receptors located at the cell membrane, cytosol, or nuclear compartments and in the extracellular matrix. We have here characterized transferrin (Tf) as one of these IGFBP-3 ...
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ژورنال
عنوان ژورنال: Growth Hormone & IGF Research
سال: 2004
ISSN: 1096-6374
DOI: 10.1016/j.ghir.2003.12.009